Phage Therapy

Seeking phage therapy

The CPT has been involved in several clinical phage treatment cases. In these cases, we have identified and produced phages in collaboration with a team of medical doctors and other clinical professionals who prescribe and oversee treatments. The CPT is not able to make any diagnosis of diseases or provide treatment directly to any patient.

The CPT has been working with the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego to connect patients and their physicians with phage treatment. In general, the initial inquiry for the phage therapy suitability is made by the physician or the infectious disease specialist who has direct responsibility for patient care. The physician will then discuss the patient’s case with physicians at the IPATH for potential treatment.

Phage therapy as human medicine is still considered to be highly experimental and it may not be suitable for all cases.

Phage therapy & related publications

Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection. Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e00954-17.

Comparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy. Liu M, Hernandez-Morales A, Clark J, Le T, Biswas B, Bishop-Lilly KA, Henry M, et al. Nat Commun. 2022 Jun 30;13(1):3776.

Therapeutic Bacteriophages for Gram-Negative Bacterial Infections in Animals and Humans. Zagaliotis P, Michalik-Provasek J, Gill JJ, Walsh TJ. Pathog Immun. 2022 Oct 17;7(2):1-45.

Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections. Le T, Nang SC, Zhao J, Yu HH, Li J, Gill JJ, Liu M, Aslam S. Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0003723.

Phage Milagro: a platform for engineering a broad host range virulent phage for Burkholderia. Yao G, Le T, Korn AM, Peterson HN, Liu M, Gonzalez CF, Gill JJ.J Virol. 2023 Nov 30;97(11):e0085023. doi: 10.1128/jvi.00850-23.