PhD Candidates Adriana Hernandez Morales and Jordyn Michalik won first places at Student Research Week 2018
PBSX phagocin: an antimicrobial with adaptable specificity in a modular framework
PBSX is a temperate bacteriophage mutant of Bacillus subtilis 168 incapable of infection while maintaining antimicrobial characteristics with unit efficiency. PBSX-like defective prophages, called phagocins, are induced by the SOS response of various Bacillus genera and function as antimicrobial agents capable of targeting species other than the host. Disease caused by dysbiosis of the humanLearn More…
Molecular function of the prototype unimolecular spanin gp11 from phage T1
Spanins are bacteriophage lysis proteins responsible for disruption of outer membrane (OM), the final step of Gram-negative host lysis. The absence of spanins results in a terminal phenotype of fragile spherical cells. The phage T1 employs a unimolecular spanin (US) gp11 that has an N-terminal lipoylation signal and a C-terminal transmembrane domain (TMD). Upon maturationLearn More…