Recent work from Antillon et al on the Physiological characterization of single-gene lysis proteins is now online!
The ssRNA phage world has recently undergone a metagenomic expansion upward of a thousand fold. Each genome likely carries at least one single-gene lysis (sgl) cistron encoding a protein that single-handedly induces host autolysis. In this newest publication, Antillon et al initiated an approach to segregate the Sgls into operational types based on physiological analysis, as a first step toward the alluring goal of finding many new ways to induce bacterial death and the attendant expectations for new antibiotic development.